Recombinant Spider Silk Protein Coatings for Intravenous Catheters

Technical Summary

•  Intravenous (IV) catheters suffer from a variety of problems including, for example: 1) thrombotic occlusion (blood clot blocking passage of blood or therapy into our out of the catheter), 2) fibrin sheath deposition (fibrin sheath that occludes the catheter), and 3) infection either at the site of insertion or biofilm deposition that leads to systemic infections. Coating the IV catheter with recombinant spider silk proteins (rSSp) combats thrombosis and associated thrombotic occlusions and may also help resist fibrin sheath deposition.


Commercial Applications

•  Potential commercial partners:

•  Catheter development companies

•  Biomedical/Biotech companies


Competitive Advantages       

•  Elimination or reduction of infections relating to catheters.

•  rSSp coating adheres to silicone and polyurethane along with a variety of other materials.

•  Coatings can be functionalized with antimicrobials.


Additional Information



Related Technologies

•  Method for Upregulation of Synthetic Spider Silk Production in E. coli (P13014)

•  Method for Solubilizing Spider Silk Proteins in Aqueous Solutions (P13025)

•  Applications for Solubilized Spider Silk Proteins in Aqueous Solutions (P14002)

•  Apparatus for Synthetic Spider Silk Fiber Formation (P14036)

•  Method for Producing Spider Silk Proteins in E. Coli (P15011)

•  Blending of Recombinant Spider Silk with Nylon 6,6 for Improved Mechanical Properties (P15018)



Patent Information:
For Information, Contact:
Christian Iverson
Utah State University
Justin Jones Randolph Lewis Thomas Harris Danielle Gaztambide Breton Day