Method for Producing Spider Silk Proteins in E. coli

Technical Summary

•  Dr. Randy Lewis and Dr. Justin Jones of the Biology department at Utah State University have engineered E. coli to produce spider silk proteins in higher densities (g/L). The higher yields are enabled by a unique 3-gene vector system in E. coli tuned to the production of spider silk protein.


Commercial Applications

•  Potential uses for spider silk:

•  High performance fabrics

•  Medical applications

•  Cosmetics

•  Advanced coatings

•  Surface treatments

•  Optical enhancement

•  Bioadhesive materials

•  Advanced composites

•  Lightweight and strong yarns and ropes


Competitive Advantages

•  More protein production for the same bacteria volume

•  Produces higher volume of protein than non-E. coli systems


Related Technologies

•  Method for Upregulation of Synthetic Spider Silk Production in E. coli (P13014)

•  Method for Solubilizing Spider Silk Proteins in Aqueous Solutions (P13025)

•  Applications for Solubilized Spider Silk Proteins in Aqueous Solutions (P14002)

•  Apparatus for Synthetic Spider Silk Fiber Formation (P14036)

•  Blending of Recombinant Spider Silk with Nylon 6,6 for Improved Mechanical Properties (P15018)

•  Recombinant Spider Silk Protein Coating for Intravenous Catheters (P16025)




Patent Information:
For Information, Contact:
Christian Iverson
Utah State University
Randolph Lewis Dong Chen Sreevidhya Krishnaji Paula Oliveira
Spider Silk